H2N2V1, Main, Exploration, bibRecord, 000B91

[Genome composition analysis of the reassortant influenza viruses used in seasonal and pandemic live attenuated influenza vaccine].

Identifieur interne : 000B91 ( Main/Exploration ); précédent : 000B90; suivant : 000B92

[Genome composition analysis of the reassortant influenza viruses used in seasonal and pandemic live attenuated influenza vaccine].

Auteurs : I V Kiseleva ; J T M. Voeten ; L C P. Teley ; N V Larionova ; I A Dubrovina ; Zh A. Berdygulova ; E A Bazhenova ; H. Van Den Bosch ; J G M. Heldens ; L G Rudenko

Source :

Molekuliarnaia genetika, mikrobiologiia i virusologiia [ 0208-0613 ] ; 2011.

RBID : pubmed:22312898

Descripteurs français

KwdFr :
- ARN (génétique), ARN (isolement et purification), Animaux, Co-infection (virologie), Embryon de poulet, Grippe humaine (), Grippe humaine (épidémiologie), Génome viral (génétique), Humains, Hémagglutinines (génétique), Pandémies, Sialidase (génétique), Sous-type H1N1 du virus de la grippe A (génétique), Sous-type H1N1 du virus de la grippe A (immunologie), Sous-type H3N2 du virus de la grippe A (génétique), Sous-type H3N2 du virus de la grippe A (isolement et purification), Vaccins antigrippaux (génétique), Vaccins atténués (génétique), Vaccins atténués (immunologie), Virus influenza B (génétique), Virus influenza B (immunologie), Virus recombinants (génétique), Virus recombinants (immunologie).
MESH :
- génétique : ARN, Génome viral, Hémagglutinines, Sialidase, Sous-type H1N1 du virus de la grippe A, Sous-type H3N2 du virus de la grippe A, Vaccins antigrippaux, Vaccins atténués, Virus influenza B, Virus recombinants.
- immunologie : Sous-type H1N1 du virus de la grippe A, Vaccins atténués, Virus influenza B, Virus recombinants.
- isolement et purification : ARN, Sous-type H3N2 du virus de la grippe A.
- virologie : Co-infection.
- épidémiologie : Grippe humaine.
- Animaux, Embryon de poulet, Grippe humaine, Humains, Pandémies.

English descriptors

KwdEn :
- Animals, Chick Embryo, Coinfection (virology), Genome, Viral (genetics), Hemagglutinins (genetics), Humans, Influenza A Virus, H1N1 Subtype (genetics), Influenza A Virus, H1N1 Subtype (immunology), Influenza A Virus, H3N2 Subtype (genetics), Influenza A Virus, H3N2 Subtype (isolation & purification), Influenza B virus (genetics), Influenza B virus (immunology), Influenza Vaccines (genetics), Influenza, Human (epidemiology), Influenza, Human (prevention & control), Neuraminidase (genetics), Pandemics, RNA (genetics), RNA (isolation & purification), Reassortant Viruses (genetics), Reassortant Viruses (immunology), Vaccines, Attenuated (genetics), Vaccines, Attenuated (immunology).
MESH :
- chemical , genetics : Hemagglutinins, Influenza Vaccines, Neuraminidase, RNA, Vaccines, Attenuated.
- epidemiology : Influenza, Human.
- genetics : Genome, Viral, Influenza A Virus, H1N1 Subtype, Influenza A Virus, H3N2 Subtype, Influenza B virus, Reassortant Viruses.
- immunology : Influenza A Virus, H1N1 Subtype, Influenza B virus, Reassortant Viruses, Vaccines, Attenuated.
- isolation & purification : Influenza A Virus, H3N2 Subtype, RNA.
- prevention & control : Influenza, Human.
- virology : Coinfection.
- Animals, Chick Embryo, Humans, Pandemics.

Abstract

The cold-adapted, temperature sensitive and attenuated influenza master donor viruses A/Leningrad/134/17/57 (H2N2) and B/USSR/ 60/69 were used to generate the vaccine viruses to be included in live attenuated influenza vaccine. These vaccine viruses typically are 6:2 reassortant viruses containing the surface antigens hemagglutinin and neuraminidase of current wild type influenza A and influenza B viruses with the gene segments encoding the internal viral proteins, and conferring the cold-adapted, temperature sensitive and attenuated phenotype, being inherited from the master donor viruses. The 6:2 reassortant viruses were selected from co-infections between master donor virus and wild type viruses that theoretically may yield as many as 256 combinations of gene segments and thus 256 genetically different viruses. As the time to generate and isolate vaccine viruses is limited and because only 6:2 reassortant viruses are allowed as vaccine viruses, screening needs to be both rapid and unambiguous. The screening of the reassortant viruses by RT-PCRs using master donor virus and wild type virus specific primer sets was described to select both influenza A and influenza B 6:2 reassortant viruses to be used in seasonal and pandemic live attenuated vaccine.

PubMed: 22312898

Affiliations:

Le document en format XML

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<author><name sortKey="Voeten, J T M" sort="Voeten, J T M" uniqKey="Voeten J" first="J T M" last="Voeten">J T M. Voeten</name>
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<author><name sortKey="Teley, L C P" sort="Teley, L C P" uniqKey="Teley L" first="L C P" last="Teley">L C P. Teley</name>
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<term>Genome, Viral (genetics)</term>
<term>Hemagglutinins (genetics)</term>
<term>Humans</term>
<term>Influenza A Virus, H1N1 Subtype (genetics)</term>
<term>Influenza A Virus, H1N1 Subtype (immunology)</term>
<term>Influenza A Virus, H3N2 Subtype (genetics)</term>
<term>Influenza A Virus, H3N2 Subtype (isolation & purification)</term>
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<term>Influenza B virus (immunology)</term>
<term>Influenza Vaccines (genetics)</term>
<term>Influenza, Human (epidemiology)</term>
<term>Influenza, Human (prevention & control)</term>
<term>Neuraminidase (genetics)</term>
<term>Pandemics</term>
<term>RNA (genetics)</term>
<term>RNA (isolation & purification)</term>
<term>Reassortant Viruses (genetics)</term>
<term>Reassortant Viruses (immunology)</term>
<term>Vaccines, Attenuated (genetics)</term>
<term>Vaccines, Attenuated (immunology)</term>
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<term>ARN (isolement et purification)</term>
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<term>Co-infection (virologie)</term>
<term>Embryon de poulet</term>
<term>Grippe humaine ()</term>
<term>Grippe humaine (épidémiologie)</term>
<term>Génome viral (génétique)</term>
<term>Humains</term>
<term>Hémagglutinines (génétique)</term>
<term>Pandémies</term>
<term>Sialidase (génétique)</term>
<term>Sous-type H1N1 du virus de la grippe A (génétique)</term>
<term>Sous-type H1N1 du virus de la grippe A (immunologie)</term>
<term>Sous-type H3N2 du virus de la grippe A (génétique)</term>
<term>Sous-type H3N2 du virus de la grippe A (isolement et purification)</term>
<term>Vaccins antigrippaux (génétique)</term>
<term>Vaccins atténués (génétique)</term>
<term>Vaccins atténués (immunologie)</term>
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<term>Virus influenza B (immunologie)</term>
<term>Virus recombinants (génétique)</term>
<term>Virus recombinants (immunologie)</term>
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<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Hemagglutinins</term>
<term>Influenza Vaccines</term>
<term>Neuraminidase</term>
<term>RNA</term>
<term>Vaccines, Attenuated</term>
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<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Genome, Viral</term>
<term>Influenza A Virus, H1N1 Subtype</term>
<term>Influenza A Virus, H3N2 Subtype</term>
<term>Influenza B virus</term>
<term>Reassortant Viruses</term>
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<term>Génome viral</term>
<term>Hémagglutinines</term>
<term>Sialidase</term>
<term>Sous-type H1N1 du virus de la grippe A</term>
<term>Sous-type H3N2 du virus de la grippe A</term>
<term>Vaccins antigrippaux</term>
<term>Vaccins atténués</term>
<term>Virus influenza B</term>
<term>Virus recombinants</term>
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<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Sous-type H1N1 du virus de la grippe A</term>
<term>Vaccins atténués</term>
<term>Virus influenza B</term>
<term>Virus recombinants</term>
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<term>Influenza B virus</term>
<term>Reassortant Viruses</term>
<term>Vaccines, Attenuated</term>
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<keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Influenza A Virus, H3N2 Subtype</term>
<term>RNA</term>
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<term>Sous-type H3N2 du virus de la grippe A</term>
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<front><div type="abstract" xml:lang="en">The cold-adapted, temperature sensitive and attenuated influenza master donor viruses A/Leningrad/134/17/57 (H2N2) and B/USSR/ 60/69 were used to generate the vaccine viruses to be included in live attenuated influenza vaccine. These vaccine viruses typically are 6:2 reassortant viruses containing the surface antigens hemagglutinin and neuraminidase of current wild type influenza A and influenza B viruses with the gene segments encoding the internal viral proteins, and conferring the cold-adapted, temperature sensitive and attenuated phenotype, being inherited from the master donor viruses. The 6:2 reassortant viruses were selected from co-infections between master donor virus and wild type viruses that theoretically may yield as many as 256 combinations of gene segments and thus 256 genetically different viruses. As the time to generate and isolate vaccine viruses is limited and because only 6:2 reassortant viruses are allowed as vaccine viruses, screening needs to be both rapid and unambiguous. The screening of the reassortant viruses by RT-PCRs using master donor virus and wild type virus specific primer sets was described to select both influenza A and influenza B 6:2 reassortant viruses to be used in seasonal and pandemic live attenuated vaccine.</div>
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<affiliations><list></list>
<tree><noCountry><name sortKey="Bazhenova, E A" sort="Bazhenova, E A" uniqKey="Bazhenova E" first="E A" last="Bazhenova">E A Bazhenova</name>
<name sortKey="Berdygulova, Zh A" sort="Berdygulova, Zh A" uniqKey="Berdygulova Z" first="Zh A" last="Berdygulova">Zh A. Berdygulova</name>
<name sortKey="Dubrovina, I A" sort="Dubrovina, I A" uniqKey="Dubrovina I" first="I A" last="Dubrovina">I A Dubrovina</name>
<name sortKey="Heldens, J G M" sort="Heldens, J G M" uniqKey="Heldens J" first="J G M" last="Heldens">J G M. Heldens</name>
<name sortKey="Kiseleva, I V" sort="Kiseleva, I V" uniqKey="Kiseleva I" first="I V" last="Kiseleva">I V Kiseleva</name>
<name sortKey="Larionova, N V" sort="Larionova, N V" uniqKey="Larionova N" first="N V" last="Larionova">N V Larionova</name>
<name sortKey="Rudenko, L G" sort="Rudenko, L G" uniqKey="Rudenko L" first="L G" last="Rudenko">L G Rudenko</name>
<name sortKey="Teley, L C P" sort="Teley, L C P" uniqKey="Teley L" first="L C P" last="Teley">L C P. Teley</name>
<name sortKey="Van Den Bosch, H" sort="Van Den Bosch, H" uniqKey="Van Den Bosch H" first="H" last="Van Den Bosch">H. Van Den Bosch</name>
<name sortKey="Voeten, J T M" sort="Voeten, J T M" uniqKey="Voeten J" first="J T M" last="Voeten">J T M. Voeten</name>
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Serveur d'exploration H2N2

[Genome composition analysis of the reassortant influenza viruses used in seasonal and pandemic live attenuated influenza vaccine].

[Genome composition analysis of the reassortant influenza viruses used in seasonal and pandemic live attenuated influenza vaccine].

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

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